When she was 12, she was cast in a Nickelodeon show and signed her first contract with Da Family/Blackground/Universal Records. Her debut album JoJo went multi-platinum, breaking the record for the youngest solo artist ever to have a #1 hit on the Billboard Pop Charts as well as the youngest artist ever to be nominated for an MTV Video Music Award. She toured Europe with Usher to promote the album.
In December 2004, Levesque performed for President Bush and First Lady Laura Bush. She was invited back again to perform for America's Youth Rocks the Nation at the Washington D.C. Armory in 2005. She also performed the national anthem at the Orange Bowl.
Levesque made her feature film debut in Aquamarine.