Cheryl Cole, JLS and Dizzee Rascal will join them at the radio station's annual extravaganza, which takes place at Vaynol Estate, Bangor, North Wales on May 22 and 23.
Other acts taking to the stage include Scouting For Girls, Pixie Lott, Ellie Goulding, Vampire Weekend, Biffy Clyro, Lostprophets, Justin Bieber and Marina And The Diamonds.
Jason Carter from Radio 1 said: "We've pulled out all the stops for our tenth Radio 1's Big Weekend with an outstanding line-up of the best UK and international talent, along with new and emerging artists."
