Some fans are speculating that a film spin-off will be made to wrap-up the canceled show.
But the actress - who played cheerleader Claire Bennet - doesn't know if it's going ahead.
Panettiere adds that she would be interested in the movie if it was given the go ahead. "It would be fun to do, but I know nothing about it."
As for her role on Heroes, Hayden said: "I grew up on that show. I spent some of my real developmental years there, and that's my family.
"They were the best people to grow up around, and it was a great experience. And I loved playing Claire - she grew up with me, and I grew up with her."