The actress played super-powered cheerleader Claire Bennet on the NBC drama from 2006 to 2010.
Asked if she would be interested in a Heroes film, she told Collider: "Yeah, I think so. I get asked that a lot. If there is [a film], I haven’t heard about it yet, but maybe one day. Never say never."
Panettiere added that she was satisified with the way Heroes concluded, despite the show's unexpected cancellation.
Her co-star Greg Grunberg previously admitted that he is still hoping for a reunion film, while Ali Larter has claimed that the project is unlikely to happen.